St. Luke's Hospital is a former hospital building located on a bluff overlooking downtown Davenport, Iowa, United States. It is listed on the Davenport Register of Historic Properties and on the National Register of Historic Places. The Daniel Newcomb House, which became St. Luke’s Hospital, was built in the Italianate style in 1850. It is built of red brick with a shallow hipped roof, bracketed eaves and a belvedere on the top of the roof. The 1903 addition was built to compliment the older building. The pitch of the roof, however, is steeper and it includes dormers at various points. It is also a little simpler in design without the bracketed eaves. The T-plan wing nearly tripled the available floor space, and at the same time the house probably lost many of its notable exterior features